Twins vs. Tigers prediction, odds, line, start time: 2025 MLB picks, August 4 bets from proven model

The Minnesota Twins (52-59) and the Detroit Tigers (65-48) begin a three-game series among AL Central rivals on Monday. The Twins are struggling as of late, dropping four of their last five games. They defeated the Cleveland Guardians 5-4 on Sunday. The Tigers lost 2-0 to the Philadelphia Phillies last night. Casey Mize (9-4, 3.43 ERA) starts for Detroit. Minnesota hasn’t announced its starter yet. 

First pitch from Comerica Park is set for 6:40 p.m. ET. The Tigers are the -152 money-line favorites in the latest Twins vs. Tigers odds from FanDuel Sportsbook, while the over/under for total runs scored is 8. Before making any Twins vs. Tigers picks, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 19 of the 2025 MLB season a profitable 27-22 on top-rated MLB money-line picks. It has excelled in making home run prop picks this season, returning more than 40 units of profit. Anybody following its MLB betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on Twins vs. Tigers and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for Twins vs. Tigers, which you can get in on with a DraftKings promo code or a FanDuel promo code.

Why the Twins can win

Right fielder Trevor Larnach owns a .242 batting average with 13 home runs and 46 RBI on the season. In his last outing, Larnach went 2-of-5 with two singles and one RBI. Third baseman Brooks Lee can also be an offensive outlet, as he has a batting average of .247 with 10 dingers and 43 RBI.

On July 29 against the Boston Red Sox, he went 2-of-5 with two total home runs and five RBI. The Twins are also 26-25 on the year after a win and own a 24-12 run line record as the away underdog. See which team to back at SportsLine.

Why the Tigers can win

Left fielder Riley Greene is a strong run producer for Detroit, as he’s tied for eighth in the MLB in home runs (26) and sixth in RBI (84). In the July 29th win over the Diamondbacks, Greene was 3-of-5. with two doubles, one home run and three RBI. 

Right fielder Kerry Carpenter is another power hitter in the lineup. In 2025, Carpenter owns a .263 batting average with 18 dingers and 36 RBI. He has hammered a home run in two of his last four games. During Saturday’s win over the Phillies, Carpenter was 1-of-3 with a solo. See which team to back at SportsLine. 

How to make Twins vs. Tigers picks

SportsLine’s model is leaning Over on the total, projecting 9.4 combined runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model’s MLB picks. 

So who wins Twins vs. Tigers, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.