Twins vs. Reds odds, line, prediction, start time: 2025 MLB picks, June 19 best bets from proven model

The Cincinnati Reds go for a three-game sweep of the Minnesota Twins when they meet in an interleague matchup on Thursday afternoon. Cincinnati won Tuesday’s opener 6-5, before earning a rain-shortened 4-2 victory on Wednesday. The Twins (36-37), who have lost six in a row, are 16-25 on the road in 2025. The Reds (39-35), who have won four in a row, are 20-16 on their home field this season.

First pitch from Great American Ball Park in Cincinnati is set for 12:40 p.m. ET. The Reds have won six of the past nine meetings with the Twins. Cincinnati is a -114 favorite on the money line (risk $114 to win $100) in the latest Twins vs. Reds odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over-under, is 9. Before making any Reds vs. Twins picks, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 13 of the 2025 MLB season on a 37-30 run on top-rated MLB sides picks. It has excelled in making home run prop picks, returning more than 35 units of profit over the past two months. Anybody following at sportsbooks and on betting apps could have seen strong returns.   

Now, the model has set its sights on Twins vs. Reds and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for Twins vs. Reds, which you can get in on with a DraftKings promo code or a FanDuel promo code.

Why the Reds can win

Right-hander Nick Martinez (4-7, 3.92 ERA) is expected to start for Cincinnati. In 14 starts this season, he has pitched 80.1 innings, allowing 80 hits, 35 earned runs and 18 walks, while striking out 58. He is coming off an 11-5 loss at Detroit on Friday. In that outing, he pitched five innings, allowing eight hits, four earned runs and two walks, while striking out five. He earned a 13-1 win over Arizona on June 7, going six innings and allowing six hits, one earned run and one walk, while striking out six.

Helping power the Reds’ offense is center fielder T.J. Friedl. The fifth-year veteran is batting .288 in 70 games this season. He has registered 12 doubles, two triples, eight homers and 28 RBI with 45 runs scored. He has hits in seven of the last eight games, including a 2-for-5 effort with a solo home run in a 7-4 win at Cleveland on June 9. See which team to back at SportsLine.

Why the Twins can win

Right-hander Chris Paddack (2-6, 4.30 ERA) will take the mound for Minnesota. In 14 starts this season, he has logged 75.1 innings, allowing 70 hits, 36 earned runs and 23 walks, while striking out 53. In a 5-4 loss to Toronto on June 7, he received a no-decision after pitching six innings, allowing four hits, two earned runs and two walks with two strikeouts. In two career starts against Cincinnati, he is 1-1 with a 4.09 ERA, walking two and striking out 16.

Center fielder Byron Buxton is among Minnesota’s top hitters. In 56 games this season, he is hitting .274 with eight doubles, three triples, 13 homers and 43 RBI. In a 6-2 win over the Texas Rangers on June 11, he was 3-for-3 with a double, a homer and three RBI. He was 3-for-4 with a double in a 16-4 loss to Texas on June 10. In six career games against Cincinnati, he has three homers and four RBI. See which team to back at SportsLine. 

How to make Twins vs. Reds picks

SportsLine’s model is leaning Over on the total, projecting 9.6 combined runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model’s MLB picks. 

So who wins Twins vs. Reds, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.