An NL battle takes place as the Pittsburgh Pirates (44-62) and the San Francisco Giants (54-52) square off on Monday. The Pirates have strung together two consecutive wins, shutting out the Arizona Diamondbacks 6-0 on Sunday. On the other side, San Francisco was swept by the New York Mets in three games, falling 5-3 in their last contest. Mitch Keller (4-10, 3.53 ERA) starts for the visiting team, and Carson Whisenhunt is making his MLB debut for the Giants.
First pitch from Oracle Park is set for 9:45 p.m. ET. San Francisco is a -132 favorite (risk $132 to win $100) in the latest Pirates vs. Giants odds from DraftKings Sportsbook, while Pittsburgh is a +109 underdog (risk $100 to win $109). The over/under for total runs scored is 7.5. Before making any Pirates vs. Giants picks, be sure to see the MLB betting predictions from SportsLine’s proven model. Bet on Pirates vs. Giants and every other MLB game at DraftKings, where you can get $150 in bonus bets instantly with the latest DraftKings promo code:
The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 19 of the 2025 MLB season 27-22 on top-rated MLB money-line picks. It has excelled in making home run prop picks this season, returning more than 40 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns, especially when paired with the latest BetMGM promo code and FanDuel promo code, just to name a few. At BetMGM, new users can get up to $1,500 back in bonus bets if their first bet loses.
Here are the model’s three best bets for Pirates vs. Giants on Monday:
- Heliot Ramos Under 1.5 total bases (-155)
- Jung Hoo Lee Over 1.5 total hits (+185)
- Max Keller Over 4.5 strikeouts (-115)
Heliot Ramos Under 1.5 total bases (-155)
Ramos presently has a team-high .268 batting average with 14 home runs and 50 RBI. His over/under on DraftKings is set at 1.5, but he hasn’t been consistent in that area. He’s gone under in six of his last 10 outings. On Sunday against the Mets, he was 0-3 with a walk. The model also projects him to log 1.4 total bases in this game.
Jung Hoo Lee Over 1.5 total hits (+185)
Lee enters this game with a .252 batting average with six home runs and 42 RBI this season, but the month of July has been solid. He’s hitting .304 in the month with 21 total hits. The 26-year-old has cleared 1.5 hits in three of his last five games. On Saturday, Lee went 3-of-4 with a double and one run driven in.
Mitch Keller Over 4.5 strikeouts (-115)
Keller’s strikeout line is set at 4.5 on DraftKings. This season, he has 97 Ks and has gone over that number in 9 of his last 15 games. The model projects him to throw 4.9 Ks in this NL tilt. In his last start against the Tigers on July 22, Keller had five strikeouts.
Want more MLB picks for Monday?
You’ve seen the model’s MLB picks for Pirates vs. Giants on Monday. Now, get more MLB picks from No. 1 expert Bruce Marshall, who is up more than 15 units on his last 111 MLB picks.
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