Pirates vs. Brewers odds, line, prediction, time: 2025 MLB picks, June 25 best bets from proven model

Two of Major League Baseball’s most exciting young pitchers square off when the Pittsburgh Pirates battle the Milwaukee Brewers on Wednesday afternoon. Pittsburgh will send righthander Paul Skenes (4-6, 1.85 ERA) to the mound, while Milwaukee counters with righthander Jacob Misiorowski (2-0, 1.64 ERA). The Pirates (32-49), who had a two-game winning streak snapped on Tuesday, are 12-28 on the road this season. The Brewers (44-36), who have won five of six, are 24-16 on their home field in 2025.

First pitch from American Family Field in Milwaukee is set for 2:10 p.m. ET. The Brewers have won six of the last 10 meetings. Milwauee is a -112 favorite on the money line (risk $112 to win $100) in the latest Brewers vs. Pirates odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 6.5. Before making any Pirates vs. Brewers picks, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 14 of the 2025 MLB season on a profitable 41-32 run on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 22 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns.   

Now, the model has set its sights on Pirates vs. Brewers and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for Pirates vs. Brewers, which you can get in on with a DraftKings promo code or a FanDuel promo code.

Why the Pirates can win

Skenes has been dominant on the mound, topping 100 mph consistently. In 16 starts, he has logged 102 innings pitched, allowing 21 earned runs and 27 walks, while striking out 106. In an 8-4 win at Detroit on Thursday, he received a no-decision despite pitching six innings, allowing three hits, two earned runs and five walks with nine strikeouts. He has allowed three or fewer earned runs in all but one outing this year.

Right fielder Andrew McCutchen, a former first-round selection by the Pirates in 2005, is among the team’s top hitters. In 71 games this season, he is hitting .259 with 13 doubles, eight homers and 28 RBI. He has hits in seven of the last nine games. He was 2-for-4 with a homer and one RBI in Thursday’s win over Detroit. See which team to back at SportsLine.

Why the Brewers can win

Misiorowski has been nearly unhittable since being called up two weeks ago. In 11 innings pitched, he has allowed just two earned runs on one hit with five walks and 11 strikeouts. His fastball has consistently been recorded at or over 100 mph. In Friday’s 17-6 win over the Minnesota Twins, he had a perfect game through six innings. When he came out after a long delay for the seventh, he issued a walk, before giving up a home run to Minnesota’s Matt Wallner.

Offensively, designated hitter Christian Yelich has been on a tear. He is on an eight-game hitting streak, including six multi-hit performances. In Friday’s win over the Twins, Yelich set a Major League Baseball record with eight RBI without scoring a run himself. In 75 games this season, he is hitting .264 with 10 doubles, 15 homers, 56 RBI and 12 stolen bases. Since May 21, he has raised his batting average 80 points. See which team to back at SportsLine. 

How to make Pirates vs. Brewers picks

SportsLine’s model is leaning Over on the total, projecting 7.2 combined runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model’s MLB picks. 

So who wins Pirates vs. Brewers, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.