Ole Miss vs. Oklahoma prediction, odds, line, spread, picks, best bets from proven model

The No. 8 Ole Miss Rebels (6-1) and the No. 13 Oklahoma Sooners (6-1) link up on Saturday afternoon in a critical SEC matchup with both conference and College Football Playoff implications. The Rebels had their six-game win streak halted last weekend in a 43-35 loss at Georgia. Meanwhile, Oklahoma took down South Carolina 26-9. Oklahoma lists running back Jovantae Barnes and defensive back Gentry Williams as doubtful.

Kickoff from the Gaylord Family-Oklahoma Memorial Stadium in Norman, Okla., is at noon ET. The Sooners are 4.5-point favorites in the latest Ole Miss vs. Oklahoma odds, while the over/under for total points scored is 52.5 via SportsLine consensus. Before making any Oklahoma vs. Ole Miss picks, check out the college football predictions from the SportsLine Projection Model. 

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The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 42-30 combined on money-line and over/under college football picks since the beginning of 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on Ole Miss vs. Oklahoma. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Ole Miss vs. Oklahoma:

Why Ole Miss can cover

Lane Kiffin’s offense has been dynamic all season long. They are third in the SEC in total offense (491.9) and fourth in scoring offense (37.4). Senior quarterback Trinidad Chambliss has stepped in at quarterback following an early-season ankle injury to Austin Simmons, and has 1,549 passing yards with eight passing touchdowns. He’s thrown for 250-plus passing yards and a passing score in five straight games. 

Sophomore running back Kewan Lacy comes into this game third in the SEC in rushing yards (618) and second in rushing touchdowns (10). The Texas native has three games with 100-plus rushing yards and a score this season. He found the end zone twice last week. See which team to back at SportsLine. 

Why Oklahoma can cover

Junior quarterback John Mateer is a dual-threat playmaker under center. Mateer has 1,567 passing yards, 209 rushing yards and 12 total touchdowns. The main target in the passing game has been junior receiver Isaiah Sategna III. He has 37 catches for 493 receiving yards and four touchdowns. 

In his last outing, Sategna III had 73 receiving yards and a score. Senior defensive linemen R Mason Thomas is getting into the backfield, leading the team in sacks (5.5) with 20 total tackles. Oklahoma is 1-0 ATS against ranked opponents and 3-2-1 ATS as the favorite in 2025. See which team to back at SportsLine.

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How to make Ole Miss vs. Oklahoma picks

SportsLine’s model is going Under on the total, projecting 49 combined points. It also says one side of the spread hits in nearly 70% of simulations. You can only get the pick at SportsLine. 

So who wins Ole Miss vs. Oklahoma, and which side of the spread hits nearly 70% of the time? Visit SportsLine now to see which side of the Ole Miss vs. Oklahoma spread to jump on, all from the advanced model that finished up over $2,000 on its FBS college football picks since its inception, and find out.