Oklahoma vs. Tennessee prediction, odds, picks, Week 10 college football best bets from proven model

A top-20 SEC matchup features the No. 18 Oklahoma Sooners (6-2) and the No. 14 Tennessee Volunteers (6-2) battling on Saturday afternoon. The Sooners have lost two of their last three games, falling 34-26 to Ole Miss in Week 9. Tennessee defeated Kentucky 56-34. on the road last week. Oklahoma leads the all-time series 3-2, but the Volunteers beat the Sooners 25-15 in 2024 in Tennessee coach Josh Heupel’s return to his alma mater. Starting linebacker Arion Carter is questionable for Tennessee. 

Kickoff from Neyland Stadium in Knoxville, Tenn., is at 7:30 p.m. ET. The Volunteers are 2.5-point favorites in the latest Oklahoma vs. Tennessee odds, while the over/under for total points scored is 55.5. Before making any Tennessee vs. Oklahoma picks, check out the college football predictions from the SportsLine Projection Model. 

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The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks, and it enters Week 10 on a profitable 47-33 combined run on money-line and over/under college football picks since the beginning of 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on Oklahoma vs. Tennessee. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Oklahoma vs. Tennessee:

Why Oklahoma can cover

Tennessee’s defense has struggled this season without some of its top cornerbacks, and OU quarterback John Mateer has the ability to extend plays with his feet when needed, giving them a dual-threat under center. This season, he has 1,790 passing yards, 226 rushing yards and 13 total touchdowns. 

Junior receiver Isaiah Sategna III has been his top target. He has 624 receiving yards and five touchdowns this season. Last week against Ole Miss, Sategna III had a season-high 131 receiving yards and a score. Meanwhile, freshman running back Tory Blaylock has logged 401 rushing yards and four rushing touchdowns. Oklahoma is 2-0 ATS as the road team this season as well. See which team to back at SportsLine. 

Why Tennessee can cover

Senior quarterback Joey Aguilar has strong arm and can push the ball downfield. Aguilar has 2,344 passing yards and 18 passing touchdowns. In his last outing, he went 20-of-26 for 396 passing yards and three passing scores. 

Junior receiver Chris Brazzell II is seventh in the nation in receiving yards (740) with 43 catches and eight touchdowns. The Texas native has gone over 100 receiving yards in three games this campaign. On Oct. 25 versus Kentucky, Brazzell II reeled in four passes for 138 receiving yards and a score. See which team to back at SportsLine.

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How to make Oklahoma vs. Tennessee picks

SportsLine’s model is going under on the total, projecting 52 combined points. It also says one side of the spread is the better value. You can only get the pick at SportsLine. 

So who wins Oklahoma vs. Tennessee, and which side of the spread is the better value? Visit SportsLine now to see which side of the Oklahoma vs. Tennessee spread to jump on, all from the advanced model that finished up over $2,000 on its FBS college football picks since its inception, and find out.