Two of the top three scoring offenses will meet on ‘Thursday Night Football,’ providing quite the NFL DFS player pool for the Dallas Cowboys vs. Detroit Lions matchup at 8:15 p.m. ET. Dak Prescott, Jared Goff, Jahmyr Gibbs and CeeDee Lamb are names known to casual football fans and names very familiar with being included in NFL DFS lineups. However, Detroit could be shorthanded with both Amon-Ra St. Brown and Sam LaPorta deal with injuries, so you may have to dig a little deeper in the Lions roster to find TNF DFS picks.
Wideout Isaac TeSlaa played 92% of snaps in Detroit’s last game and scored his third touchdown of the year. Daily Fantasy football lineups need economical options like TeSlaa to balance out the highly-priced stars. The Cowboys also have NFL daily Fantasy sleepers who could provide a great return on investment on TNF. Before making any Lions vs. Cowboys NFL DFS picks for ‘Thursday Night Football,’ be sure to check out the NFL DFS advice, strategy, and stacks from SportsLine daily Fantasy expert Mike McClure.
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McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him could be way up.
Now, McClure has turned his attention to ‘Thursday Night Football’ and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.
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Top NFL DFS picks for Cowboys vs. Lions
One of McClure’s top NFL DFS picks for ‘Thursday Night Football’ is Cowboys receiver CeeDee Lamb. The wideout is coming off a 7-112-1 stat line on Thanksgiving versus Kansas City, with the 112 yards matching a season high. Lamb is averaging 82.7 receiving yards per game in 2025, which ranks sixth-best in the NFL, and his career high of 227 yards came versus Detroit in 2023. This year’s Lions team has allowed the third-most touchdowns to opposing wideouts, and now it will be without starting cornerback, Terrion Arnold (shoulder), who was placed on injured reserve on Monday. See who else to roster at SportsLine.
McClure is also rostering Lions running back Jahmyr Gibbs, who has been a one-man show over the last half-dozen games. Gibbs is averaging 152.3 scrimmage yards with eight total touchdowns over his last six contests, compared to 83.7 yards and five scores over his first six games. The two-time Pro Bowler is on pace for career highs in rushing yards, rushing average, receptions and receiving yards, with his 2025 production coming versus defenses much more stout than what Dallas possesses. The Cowboys have allowed the second-most points and the fourth-most yards this season, as Gibbs should produce both in the redzone and in between the 20s. See more NFL DFS picks at SportsLine.
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How to set Lions vs. Cowboys NFL DFS lineups
McClure is targeting another undervalued player who could explode for huge numbers on ‘Thursday Night Football’. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of McClure’s NFL DFS picks, at SportsLine.
So who is Mike McClure including in his optimal NFL DFS lineups for ‘Thursday Night Football’, and which under-the-radar player offers huge value? Visit SportsLine now to see optimal NFL DFS picks, NFL DFS rankings, NFL DFS advice and NFL DFS stacks, all from a daily Fantasy expert with more than $2 million in winnings, and find out.
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