The Carolina Panthers and San Francisco 49ers will put a bow on NFL Week 12 at 8:15 p.m. ET, making it the opportune time to create a ‘Monday Night Football’ same-game parlay. Your MNF SGP could utilize NFL player props, spread bets, over/under predictions or more. With Christian McCaffrey facing his former squad for the first time, perhaps his NFL prop bets could be of interest? The latest NFL odds have the Niners as 7.5-point home favorites, with a total of 49.5. Other prop lines of note include Brock Purdy over/under 254.5 passing yards and Bryce Young over/under 208.5 passing yards.
McCaffrey has hit the Over with both his receptions and receiving yards props in each of his last five games versus teams with winning records. Knowing the betting trends is the first step to making the correct pick selections to form a winning NFL SGP. Before locking in any 49ers vs. Panthers picks for your ‘Monday Night Football’ SGP, be sure to see the Panthers vs. 49ers prop predictions powered by SportsLine’s Machine Learning AI.
LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month at SportsLine for $1 JOIN NOW.
New users can target the DraftKings promo code, which offers $200 in bonus bets if your bet wins + 3 months of NBA League Pass:
Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each player prop.
Now, the model has analyzed 49ers vs. Panthers on ‘Monday Night Football’ and locked in three confident best bets for an NFL SGP. If you successfully parlay its picks, you’d be looking at a payout of over 6-1. You can only see the Machine Learning Model player prop predictions for San Francisco vs. Carolina here.
New users can check out the latest bet365 bonus code to get $150 in bonus bets after placing a $5 bet:
Top Monday Night Football SGP picks
After simulating Panthers vs. 49ers, SportsLine AI says Panthers QB Bryce Young goes Over 208.5 passing yards (-112). The former No. 1 overall pick is coming off a career day with 448 passing yards versus Atlanta last week, which was 120 more than his previous career high. His passing touchdowns (three), yards per attempt (10.0) both matched or set highs for Young, while his passer rating (123.2) was the second-highest mark of his three NFL seasons. This all came versus a Falcons defense which ranks No. 6 versus the pass, while the Niners rank 28th in pass defense.
San Fran ranks last in defensive sacks and QB hits, with additional bottom-five rankings in defensive interceptions, completion percentage allowed and passer rating allowed. The Niners allowed Jacoby Brissett to go off for 452 passing yards and an NFL-record of 47 completions in Week 11. With that, Young is projected to have 250.2 passing yards on average, as this NFL prop rated 4.5 stars could be a part of a winning Monday Night Football SGP. See which other MNF same-game parlay picks to make here, and bet this prop here:
How to make 49ers vs. Panthers SGP picks
In addition, the SportsLine Machine Learning Model has six other NFL props that are rated 4.5 stars or better, including one that returns plus money, that could be a part of your Panthers vs. 49ers SGP picks. You can only see the Machine Learning Model’s Monday Night Football NFL parlay at SportsLine.
What are the model’s top same-game parlay picks you should target with your 49ers vs. Panthers predictions? Visit SportsLine now to see the Monday Night Football SGP from the SportsLine Machine Learning Model and find out.




Add Comment