Mariners vs. Blue Jays MLB ALCS Game 6 predictions, line, odds, best bets by proven model

The Seattle Mariners will look to punch their ticket to their first World Series when they take on the Toronto Blue Jays in Game 6 of their American League Championship Series on Sunday. Seattle grabbed a 3-2 lead in their best-of-seven series on Friday with a 6-2 win. The Mariners (90-72), who won the AL West, are 3-1 on the road this postseason. The Blue Jays (94-68), who won the AL East, are 2-2 on their home field in the playoffs.

First pitch from Rogers Centre in Toronto is set for 8:03 p.m. ET. The Blue Jays have won five of the last eight meetings with the Mariners. Toronto is a -125 favorite on the money line (risk $125 to win $100) in the latest Mariners vs. Blue Jays odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over-under, is 8. Before making any Mariners vs. Blue Jays picks, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model. 

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The SportsLine Projection Model simulates every MLB game 10,000 times. It enters the ALCS and NLCS rounds of the 2025 MLB playoffs a profitable 35-29 on top-rated MLB money-line picks this season. It has excelled making home run prop picks this season, returning nearly 30 units of profit. Anybody following its MLB betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on Mariners vs. Blue Jays and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for Blue Jays vs. Mariners:

Why the Blue Jays can win

Toronto is expected to send rookie right-hander Trey Yesavage (1-0, 3.21 ERA) to the mound. In three regular-season games, Yesavage pitched 14 innings, allowing 13 hits and five earned runs with seven walks and 16 strikeouts. He is 1-1 in the postseason. He had a solid outing in a 13-7 win over the New York Yankees on Oct. 5 in the ALDS, but was rocked in a 10-3 ALCS Game 2 loss to the Mariners. In the win over New York, he pitched 5.1 innings, allowing no hits and one walk, while striking out 11.

First baseman Vladimir Guerrero has powered Toronto all regular and postseason. The five-time All-Star has a 1.495 OPS in this year’s playoffs, with five home runs and 11 RBI across nine games. He’s also had lots of career success versus Seattle starter, Logan Gilbert, going 6 for 17 (.353) with four of those six knocks going for extra bases. See which team to back at SportsLine.

Why the Mariners can win

Although Seattle has yet to name a starter, it is expected to go with Game 2 starter Logan Gilbert (6-6, 3.44 ERA). He received a no-decision in that game, pitching three innings and allowing five hits, three runs – two earned – with one walk and two strikeouts. Among Seattle’s top hitters is first baseman Josh Naylor. For the season, he hit .295 with 20 homers, 92 RBI and 81 runs scored. He was acquired in a midseason trade with the Arizona Diamondbacks.

Also helping power the offense is center fielder Julio Rodriguez. In 160 regular-season games, he hit .267 with 31 doubles, four triples, 32 homers and 95 RBI with 30 stolen bases. He has cooled down the last two games of the series after a hot start in Toronto for Games 1 and 2. Although he is batting .235 in five games, he has two homers and five RBI. See which team to back at SportsLine. 

How to make Mariners vs. Blue Jays picks

SportsLine’s model is leaning Over on the total, projecting 9.0 combined runs. It says one side of the money line has all of the value. You can head to SportsLine to see the model’s MLB picks. 

So who wins Mariners vs. Blue Jays, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.