The New York Mets are traveling to play the San Francisco Giants in an NL showdown during Friday’s MLB schedule. Prior to the Giants’ two-game win streak, they dropped six straight games. Meanwhile, the Mets have won four straight games, including a 6-3 victory over the Angels on Wednesday. The Mets are +114 underdogs in Friday MLB odds, which is one of the longshots that SportsLine’s model is targeting.
The biggest underdog, according to the latest MLB odds for Friday, is the Marlins, who are priced at +195 on the road against the Milwaukee Brewers. Before making any MLB picks or building any MLB parlays, you’ll want to see the MLB predictions and betting advice from SportsLine’s proven computer simulation model. Bet on every MLB game at DraftKings Sportsbook, where you can get $150 in bonus bets instantly with the latest DraftKings promo code:
The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 17 of the 2025 MLB season 46-43 on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 40 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns. Also see the model’s picks for Braves vs. Rangers.
The model has broken down the MLB betting odds for Monday and just revealed its top MLB longshot picks. Combining the model’s three picks into an MLB parlay at BetMGM Sportsbook would result in a payout of +873 (risk $100 to win $873). New users can even take advantage of the BetMGM bonus code offering up to $1,500 in bonus bets if their first bet loses. Click here to claim the offer.
Here are its best longshot bets for the MLB slate on Friday
- Red Sox money line vs. Phillies (+102)
- Manny Machado to record an RBI (+125)
- Mets money line vs. Giants (+114)
- Combine these picks for a shot at a +873 payout (odds subject to change). Bet now at BetMGM, where you can get up to $1,500 in bonus bets if you don’t win.
Red Sox money line vs. Dodgers (+102)
Boston is 12-4 in their last 16 games and has found a way to string together some wins. The Red Sox are coming off a 9-8 win over the Philadelphia Phillies in extra innings on Wednesday, where Romy Gonzalez belted a grand slam. Los Angeles has struggled post-All-Star break, dropping four of their last six games. The Dodgers have Emmet Sheehan on the hill, who owns a 4.41 ERA this season. The model projects Boston winning in 50% of the simulations, making the Red Sox the value play as underdogs.
Manny Machado to record an RBI (+125)
Machado enters this game leading San Diego in batting average (.289), home runs (19), RBI (63), and hits (114). He’s going up against Cardinals starting pitcher Miles Mikolas, who is 5-7 with a 5.20 ERA this season. Machado has driven in a run in two straight games, and the model has him logging 0.7 RBIs in the latest simulations for this contest, making this +125 prop great value.
Mets money line vs. Giants (+114)
New York has seemingly found its groove, as it swept the Los Angeles Angels in their last series. Although the Giants won two straight games, they came against a struggling Atlanta Braves team. Prior to the wins, they dropped seven out of eight games. On the other side, New York is on a four-game winning streak. They also have Clay Holmes taking the mound, who is 8-5 on the season with a 3.48 ERA. The model has New York winning 42% of simulations, making this an underdog worth backing.
Want more MLB picks for today?
You’ve seen some of the model’s MLB best longshot bets for Friday. Now, get run line, total and money-line picks for every game here, all from the model that’s simulated every game 10,000 times.
Also at SportsLine:
You can also see today’s top MLB picks from expert Bruce Marshall, who’s on a sizzling 62-51-1 roll on his last 114 MLB picks. Visit SportsLine to see his best plays for today, all from the expert who’s up nearly 17 units.
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