Dodgers vs. Guardians odds, line, prediction, start time: 2025 MLB picks, May 28 best bets from proven model

The Los Angeles Dodgers will look for the series sweep when they battle the Cleveland Guardians in the final game of their three-game interleague series on Wednesday. Los Angeles earned a 7-2 win on Monday and a 9-5 triumph on Tuesday. The Dodgers (34-21), who have won two in a row, are 15-13 on the road this season. The Guardians (29-25), who have dropped three straight, are 14-10 on their home field in 2025.

First pitch from Progressive Field in Cleveland is set for 1:10 p.m. ET. The Dodgers have won six of the past seven meetings with the Guardians. Los Angeles is a -149 favorite on the money line (risk $149 to win $100) in the latest Dodgers vs. Guardians odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 9. Before making any Dodgers vs. Guardians picks, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 10 of the 2025 MLB season on a profitable 27-21 run (56%) on top-rated MLB betting picks. Anybody following at sportsbooks and on betting apps could have seen strong returns.

Now, the model has set its sights on Dodgers vs. Guardians and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for Guardians vs. Dodgers, which you can get in on with a DraftKings promo code or a FanDuel promo code.

Why the Dodgers can win

Left-hander Clayton Kershaw (0-0, 7.50 ERA) is expected to take the mound for Los Angeles. Kershaw, who is coming back from injury, will be making his third start of the season. In his last outing, he pitched two innings in a 7-5 win over the New York Mets, allowing no hits, one walk with one strikeout. The 13-year veteran has 431 career starts with a 212-94 record and 2.51 ERA.

Shohei Ohtani continues to help power the Los Angeles offense. He has hits in seven of the last nine games, including a 3-for-5 performance with one RBI in a 6-4 loss to the Los Angeles Angels on May 18. In Monday’s win over the Guardians, Ohtani homered and scored three runs. He also homered and drove in two runs on Tuesday. In 53 games this season, he is hitting .296 with nine doubles, four triples, 20 homers and 35 RBI. See which team to back at SportsLine.

Why the Guardians can win

Cleveland is expected to start right-hander Slade Cecconi (1-1, 3.27 ERA). In two starts, he has pitched 11 innings, allowing four earned runs with two walks and 14 strikeouts. He is coming off a 3-1 win at Detroit on Friday, pitching six innings and allowing five hits, one earned run with two walks and six strikeouts. This will be his third career start against the Dodgers.

Left fielder Steven Kwan helps power the Cleveland offense. In 53 games this season, he is hitting .314 with 12 doubles, four homers, 19 RBI and 28 runs scored. He has hits in six of his last seven games. In a 3-1 win over the Detroit Tigers on Friday, he was 3-for-5 with one double and one RBI. He was 1-for-3 on Tuesday. See which team to back at SportsLine. 

How to make Dodgers vs. Guardians picks

SportsLine’s model is leaning Over on the total, projecting 10.1 combined runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model’s MLB picks. 

So who wins Dodgers vs. Guardians, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.