The St. Louis Cardinals (47-38) travel to play the Pittsburgh Pirates (35-50) in an NL Central showdown on Monday to kick off their three-game series. Both teams are heading into this game securing three consecutive victories. St. Louis defeated the Cleveland Guardians 7-0 on Sunday. Meanwhile, the Pirates torched the Mets 12-1. Erick Fedde (3-7, 4.11 ERA) starts for the Cardinals. Andrew Heaney (3-7, 4.48 ERA) takes the mound for Pittsburgh.
First pitch from PNC Park in Pittsburgh is set for 6:40 p.m. ET. Pittsburgh is a -110 favorite (risk $110 to win $100) in the latest Cardinals vs. Pirates odds from DraftKings Sportsbook, while St. Louis is a slight -109 underdog (risk $109 to win $109). The over/under for total runs scored is 9. Before making any Cardinals vs. Pirates picks, be sure to see the MLB predictions from SportsLine’s proven model.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 14 of the 2025 MLB season on a profitable 41-32 run on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 22 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns, especially when paired with the latest BetMGM promo code and FanDuel promo code, just to name a few.
Here are the model’s three best bets for Cardinals vs. Pirates on Monday:
- Willson Contreras Under 1.5 hits (-260)
- Bryan Reynolds 2+ Hits (+175)
- Erick Fedde Over 3.5 Strikeouts (-155)
Willson Contreras Under 1.5 hits (-260)
Contreras is hitting .248 this season with 25 hits this month. The 33-year-old has finished with fewer than two hits in five of his last six games. The model projects 0.7 hits in this game for Contreras. In his last 10 games against the Pirates, he has a .135 batting average with five total hits.
If you want even more MLB picks, SportsLine MLB expert, Bruce Marshall, is heating up. Get his best bets for Monday, all from the expert who is 23-17-1 on his last 41 MLB picks (+834).
Bryan Reynolds 2+ Hits (+175)
Reynolds heads into this game on a seven-game hitting streak. During this stretch, the 30-year-old has compiled two-plus hits in five of those outings, including 2-of-4 in Sunday’s win over the New York Mets.
You’ve now seen the two best bets for Cardinals vs. Pirates on Monday. Now, get picks for every single game from the model that enters Week 14 of the 2025 MLB season on a 41-32 run on top-rated MLB run-line picks.
Erick Fedde Over 3.5 strikeouts (-155)
Fedde has 57 strikeouts on the season. The 32-year-old has cleared 3.5 strikeouts in four of his last six games. The model projects him to toss four K’s in this game. New users can use the latest FanDuel promo code, which offers $150 in bonus bets if your first bet of $5 or more wins.
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