Brewers vs. Pirates prediction, odds, start time: 2025 MLB picks, best bets for August 13 by proven model

The Milwaukee Brewers look to win their 12th game in a row when they battle the Pittsburgh Pirates in the last of a six-game homestand. Milwaukee earned a 14-0 win on Tuesday to extend Pittsburgh’s road woes. The Pirates (51-70), who have lost four in a row, are now just 17-41 away from home this season. The Brewers (75-44), who lead the National League Central with the best record in MLB, are 41-20 on their home field.

First pitch from American Family Field in Milwaukee is set for 2:10 p.m. ET. The Brewers have won five of the past six meetings with the Pirates. Milwaukee is a -192 favorite on the money line (risk $192 to win $100) in the latest Pirates vs. Brewers odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over-under, is 7.5. Before making any Pirates vs. Brewers picks, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model. New users can also target the DraftKings promo code, which offers $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket:

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 21 of the 2025 MLB season a profitable 31-23 on top-rated MLB money-line picks. It has excelled making home run prop picks this season, returning nearly 60 units of profit. Anybody following its MLB betting picks at sportsbooks and on betting sites could have seen strong returns.    

Now, the model has set its sights on Pirates vs. Brewers and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for Pirates vs. Brewers, which you can get in on with a DraftKings promo code or a FanDuel promo code.

Why the Brewers can win

Milwaukee is expected to send right-hander Brandon Woodruff (4-0, 2.29 ERA) to the mound. In six games this year, all starts, he has pitched 35.1 innings, allowing 17 hits, nine earned runs and six walks with 45 strikeouts. He is coming off a 3-2 win over the New York Mets on Friday. In that game, he pitched seven innings, allowing three hits, two earned runs and two walks, while striking out eight.

Helping lead the offense is rookie left fielder Isaac Collins. In 98 games this season, he is hitting .292 with 14 doubles, three triples, eight homers, 41 RBI and 47 runs scored. In Monday’s win over the Pirates, Collins was 2-for-5 with a double and a triple. He was 3-for-5 with a double and a walk-off home run in Sunday’s 7-6 win over the New York Mets. See which team to back at SportsLine.

Why the Pirates can win

Right-hander Mitch Keller (5-10, 3.86 ERA) is expected to start for Pittsburgh. In 24 games this year, all starts, he has logged 137.2 innings, allowing 133 hits, 59 earned runs and 37 walks with 107 strikeouts. He is coming off a no-decision in a 3-2 win over the Cincinnati Reds on Friday. In that game, Keller pitched 5.2 innings, allowing six hits, two earned runs and three walks, while striking out three. In a 2-1 win over the Brewers on May 24, he received a no-decision, but pitched six innings, allowing seven hits, one earned run and no walks with seven strikeouts.

Helping spark the Pirates offense is shortstop Isiah Kiner-Falefa. The eighth-year veteran is hitting .271 with 16 doubles, two triples, one homer and 32 RBI. He was 3-for-5 with a double and two RBI in a 14-8 loss to the Reds on Sunday. He was 3-for-5 with a double and three RBI in a 17-16 loss to the Colorado Rockies on Aug. 1. See which team to back at SportsLine. 

How to make Brewers vs. Pirates picks

SportsLine’s model is leaning Under on the total, projecting 7.4 combined runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model’s MLB picks. 

So who wins Pirates vs. Brewers, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.