Indiana vs. Purdue prediction, odds, time, spread: 2026 college basketball picks from proven model

A pair of in-state conference rivals will clash on Tuesday’s college basketball schedule as the No. 12 Purdue Boilermakers visit the Indiana Hoosiers. The Boilermakers (17-3, 7-2 Big Ten) have dropped back-to-back outings, most recently falling 88-82 to Illinois on Saturday. The Hoosiers (13-7, 4-5 Big Ten) ended a four-game skid on Friday by defeating Rutgers, 82-59. 

Tipoff is at 9 p.m. ET from Simon Skjodt Assembly Hall in Bloomington, Ind. The Boilermakers are 5.5-point favorites in the latest Purdue vs. Indiana odds from DraftKings Sportsbook, while the over/under for total points scored is 150.5, down a point from the opening line. Before making any Indiana vs. Purdue picks, check out the men’s college basketball predictions and betting advice from the SportsLine Projection Model.

New users can target the DraftKings promo code, which offers $300 in bonus bets if your $5+ bet wins:

The SportsLine Projection Model simulates every college basketball game 10,000 times and it enters Week 13 on a sizzling 10-1 run on its top-rated over/under college basketball picks dating back to last season, and it is on a 6-0 roll on college basketball side picks. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen strong returns.

Now, the model has simulated Purdue vs. Indiana 10,000 times and just revealed its coveted men’s college basketball picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several men’s college basketball odds and men’s college basketball betting lines for Indiana vs. Purdue:

New users can check out the latest bet365 bonus code to get $200 in bonus bets after placing a $5 bet:

How to make Indiana vs. Purdue picks

SportsLine’s model has simulated Purdue vs. Indiana 10,000 times and is going Over on the total (151.5 points). Purdue has been on a run with the Over as of late as Boilermakers’ games have eclipsed the total at a 6-2 clip over the last eight. A big reason for that is Purdue’s highly efficient offense, which ranks second in KenPom’s offensive rating as Matt Painter’s crew is eighth in the nation in field goal percentage.

As for the Hoosiers, their offense is ahead of their defense as they are 28th, nationally, in offensive efficiency compared to 57th on the defensive end. Indiana is projected to have the leading scorer in this contest, with Lamar Wilkerson surpassing 20 points, as he’s one of eight total players forecasted to reach double-digits. That allows the Over to hit with points to spare with the model calling for 158 combined points. Thus, the Over hits 65.3% of the time.

The model also says one side of the spread hits nearly 60% of the time. You can only see that pick at SportsLine.

So who wins Indiana vs. Purdue, and which side of the spread hits nearly 60% of the time? Visit SportsLine now to see which side of the Purdue vs. Indiana spread to back, all from the advanced model that has simulated this game 10,000 times, and find out.