The ACC Tigers host the SEC Tigers as No. 4 Clemson faces No. 9 LSU in a must-see Week 1 battle on Saturday night. Clemson finished its 2024 season 10-4 overall and 7-1 in conference play before defeating SMU to win the conference. They host an LSU side that finished 9-4 and has a long list of players returning this season.
Kickoff from Memorial Stadium in Clemson is set for 7:30 p.m. ET. Clemson is a 4.5-point favorite in the latest LSU vs. Clemson odds from SportsLine consensus, while the over/under for total points scored is set at 56.5. Before making any Clemson vs. LSU picks, make sure you check out the picks from the SportsLine projection model. New users at bet365 can get $200 in bonus bets instantly with the latest bet365 bonus code for Saturday’s game:
The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and was a profitable 27-16 combined on money-line and over/under college football picks in 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.
Here are SportsLine model’s best bets for Clemson vs. LSU on Saturday:
LSU +4.5
Clemson is tough to beat at home, but it also lost all three games it played against SEC teams last season. LSU is looking for its first win in Week 1 since Joe Burrow was under center in 2019, but SportsLine’s model has Brian Kelly’s team pulling off an outright upset. The model projects the SEC Tigers will cover the spread in 63% of simulations and win outright 57% of the time.
Over 56.5
Clemson rebounded from a ghastly 34-3 loss to Georgia in Week 1 last season to become one of the ACC’s offensive juggernauts. Quarterback Cade Klubnik is a Heisman-caliber talent who threw for 3,639 yards with a staggering 36 touchdowns and just six interceptions. He will lead his team at home against an LSU side that gave up 24.3 points per game last season, which was third-most in the SEC. The Over hits in 61% of simulations according to the SportsLine projection model.
Want more college football picks for Week 1?
You’ve seen the model’s top Clemson vs. LSU picks for Week 1. Now, get against the spread, total and money-line picks for every Week 1 CFB game here, all from the model that’s simulated every game 10,000 times.
Want more from SportsLine? See the top Week 1 college football picks from college football expert Bruce Marshall, who is on a 56-34-3 roll (+1833) on his last 93 CFB ATS picks.
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