The Week 0 college football schedule kicks off on Saturday, Aug. 23. Big 12 title contenders meet in the first time slot of the season as Iowa State takes on Kansas State in Dublin, Ireland at noon ET. The latest Week 0 college football odds list Kansas State as the 3-point favorite, while the over/under is 49.5. Kansas State is the pre-season favorite to win the Big 12 at +500, while Iowa State is listed at +1300.
Other Week 0 college football lines of note include Kansas (-14) vs. Fresno State and Hawaii (-2.5) vs. Stanford. Who should you target in your Week 0 college football bets for those games and others? Before locking in any Week 0 college football picks, be sure to see the latest college football predictions from SportsLine’s proven model. You can also get the latest bet365 bonus code CBSBET365, which offers $150 in bonus bets instantly:
The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and was a profitable 27-16 combined on money-line and over/under college football picks in 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.
Now, it has turned its attention to the latest college football odds for Week 0 and locked in picks for every FBS matchup. Head here to see every pick. New users can also target the DraftKings promo code, which offers new users $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket:
Top college football predictions for Week 0
One of the top college football picks the model is recommending for Week 0: Stanford (+2.5) covers on the road against Hawaii in a 7:30 p.m. ET kickoff.
Coach Timmy Chang has yet to win more than five games in a season for Hawaii and he enters this season feeling some pressure. Hawaii has traditionally been known for high-flying offenses, but the Rainbow Warriors finished ninth in the Mountain West last season with just 22 points per game. The run game was a big culprit as Hawaii ranked second to last in the league in that category.
Stanford, meanwhile, has some challenges ahead this season following the spring firing of head coach Troy Taylor. New head coach Frank Reich, however, brings NFL experience and could end up being an upgrade. Stanford also got a taste of long-distance traveling in the ACC last year, so the trip across the Pacific shouldn’t throw this program off. The model projects that Stanford wins more than 60% of the time. See which other picks the model likes here.
How to make college football picks for Week 0
The model has also made the call on who wins and covers in every Week 0 college football game, including an outright underdog that it says will win outright. You can only get every pick for every game at SportsLine.
So what college football picks can you make with confidence, and which underdog pulls off a shocking upset? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $2,000 in profit since its inception, and find out.
College football odds for Week 0
See full Week 0 college football picks, odds, predictions here
Saturday, Aug. 23
(odds subject to change)
Iowa State vs. Kansas State (-3, 49.5)
Kansas vs. Fresno State (+14, 51.5)
Sam Houston vs. Western Kentucky (-9.5, 60.5)
Stanford vs. Hawaii (-2.5, 53.5)
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