2025 NFL game-by-game predictions: Expert picks 285 games, reveals win total bets, Super Bowl futures

The Kansas City Chiefs’ reign of dominance in the AFC continued last year. Patrick Mahomes has started each of the last seven AFC Championship Games, with his team advancing to the Super Bowl in five of them, including each of the last three years. With prime contenders such as the Bills, Ravens, and Bengals, not to mention AFC West challengers, the Chargers and Broncos, it might be an uphill battle for Kansas City to remain up top, making the Chiefs a team to perhaps fade in 2026 Super Bowl futures. 

The Chiefs’ 2024 NFL win total is 11.5, with the over priced at +100 (bet $100 to win $100), while the under pays out at -120. Should you bet on Kansas City to hit the over for the seventh time in eight years, or does the under 11.5 provide better value in NFL futures bets? Making NFL picks on win totals is one of the most popular ways to bet NFL futures. Before you lock in any 2025 NFL win total picks or 2026 Super Bowl picks, you should see what SportsLine NFL expert Eric Cohen has to say, and get $150 in bonus bets when you bet $5 at bet365 right here.

Cohen, host of the weekly Early Edge NFL Prop Show, is simulating the entire regular season and playoffs. Last year in his season picks article, Cohen hit three of four win totals best bets, two of four division winner best bets, and had the Eagles to win the NFC at +600 odds. Anyone who followed Cohen’s NFL predictions likely won big. Now, he has predicted every 2025 NFL regular season game in a grid format to determine each team’s final regular season record. 

Plus he’s made his 2025 NFL playoff projections and provided best over/under bets for team wins, as well as Super Bowl LX futures for NFL betting. You can only find these picks at SportsLine. New users can also get the latest BetMGM promo code, FanDuel promo code, bet365 bonus code and DraftKings promo code to get even more value. 

Top 2025 NFL win total predictions

One team Cohen is bullish on is the Washington Commanders, who he believes will make another Cinderella run in the playoffs. Led by second year quarterback Jayden Daniels, Washington added playmaking wide receiver Deebo Samuel this offseason and looks to make the Super Bowl for the first time since the 1991 season. Though Cohen is picking them to finish the regular season with a worse record than 2024, they are among his top NFC futures bets this season.

On the flipside, Cohen is fading the New Orleans Saints, who look to be in a rebuilding phase with new coach Kellen Moore. With quarterback Derek Carr having retired, the reigns are being passed down to second round draft pick Tyler Shough or other inexperienced signal callers. With a difficult schedule on tap, the SportsLine expert does not see New Orleans winning a road game all season and is playing the under on as many win total futures of theirs as he can. See which other surprising winners Cohen is picking only at SportsLine. You can make this bet at DraftKings, where you can get $150 in bonus bets instantly with a $5 bet. 

How to get 2025 NFL season picks, projections, and best bets

Cohen has evaluated all 285 NFL games in 2025-26 and locked in his best bets for NFL win totals and Super Bowl futures. They include a potential Super Bowl result that pays approximately 65-1 and win total bets that pay back plus-money. Anyone who backs these NFL picks could hit it big. See who it is at SportsLine.

Which Super Bowl result of 65-1 could bring a huge payout, and which NFL win totals should you back for all 32 teams, including several that pay plus-money? Join SportsLine now to get Eric Cohen’s 2025 NFL projections, all from the expert who picked the Eagles to win the NFC last year at +600 odds.