The 2025 All-Star Game is in the books, and the Friday MLB schedule is loaded with 15 games, 14 coming in the evening, and all 30 MLB teams scheduled to be in action. One of the most high-profile matchups of the day is Cardinals vs. Diamondbacks at 9:40 p.m. ET in a showdown between teams looking to make playoff runs in the second half of the season. Andre Pallante (5-5, 4.49 ERA) is scheduled to be on the mound for Arizona, while Brandon Pfaadt (9-6, 5.16 ERA) is scheduled to start for the Cardinals. Arizona is a -131 favorite (risk $131 to win $100) on the money line in the latest Diamondbacks vs. Cardinals odds. The SportsLine Projection Model is calling for a higher-scoring game than the odds would suggest, with a projected combined run total of 10.1. As a result, the model is backing this game to go Over 9 runs in its MLB best bets for Friday.
Another notable matchup on Friday is Astros vs. Mariners in Milwaukee at 10:10 p.m. ET. SportsLine’s model is calling for the Mariners to win this matchup between the top two teams in the AL West standings at -135 odds. Before making any other MLB picks or building any MLB parlays, you’ll want to see the MLB predictions and betting advice from SportsLine’s proven computer model. You can also check out our MLB prop picks and MLB home run picks for Friday.
The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 17 of the 2025 MLB season 46-43 on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 40 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns.
The model has broken down the MLB odds for Friday and just revealed its top picks and MLB player props. Combining the model’s four picks into an MLB parlay would result in a payout of +853 (risk $100 to win $853). New users can even take advantage of the DraftKings promo code offering $150 in bonus bets instantly with a $5 wager.
Here are its best bets for the MLB slate on Tuesday.
- Athletics (+1.5) on the run line vs. Cleveland Guardians (-189)
- Tampa Bay Rays money line (-125) vs. Baltimore Orioles
- Cardinals-Diamondbacks Over 9 runs (-101)
- Seattle Mariners money line (-135) vs. Houston Astros
- Combine these picks for a shot at a +853 payout (odds subject to change)
Athletics (+1.5) on the run line vs. Cleveland Guardians (-189)
The Guardians and A’s both welcomed the All-Star break after both teams struggled through lengthy stretched during the first half of the season. SportsLine’s model is calling for this game to be closer than expected on Friday night. The SportsLine Projection Model is predicting a final score of 4.5-4.2 in the Guardians’ favor, with the Athletics covering on the run line in 68% of computer simulations.
Tampa Bay Rays money line (-125) vs. Baltimore Orioles
The Orioles had a disappointing first half of the 2025 season, while the Rays did enough to stay in contention in the AL East and AL Wild Card races. SportsLine’s model is backing the Rays at home on Friday night. The SportsLine Projection Model is predicting a final score of 5.0-4.3 in the Rays’ favor, with Tampa Bay covering in 62% of computer simulations.
Cardinals-Diamondbacks Over 9 runs (-101)
Both starting pitchers in this matchup have struggled at times this season with the Cardinals’ Andre Pallante entering with a 4.49 ERA and 1.30 WHIP, and Arizona’s Brandon Pfaadt entering with a 5.16 ERA and 1.31 WHIP. As such, SportsLine’s model is calling for a high-scoring game on Friday night. The SportsLine Projection Model is predicting a final score of 5.2-4.9 in the Diamondbacks’ favor, with the Over hitting in 63.5% of computer simulations.
Seattle Mariners money line (-135) vs. Houston Astros
The Mariners and Astros each have their sights set on making a run to the American League Playoffs during the second half of the season. This game will be played at T-Mobile Park in Seattle, and SportsLine’s model is giving the Mariners a slight edge. The SportsLine Projection Model is predicting a final score of 4.2-3.5 in the Mariners’ favor, with Seattle covering in 63% of computer simulations.
Want more MLB picks for today?
You’ve seen some of the model’s MLB best bets for Friday. Now, get run line, total and money-line picks for every game here, all from the model that’s simulated every game 10,000 times.
Also at SportsLine:
You can also see today’s top MLB picks from expert Matt Severance, who’s on a sizzling 183-110 roll on his last 293 MLB picks. Visit SportsLine to see his best plays for today, all from the expert who’s up over 10 units.
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