The Wednesday MLB schedule is loaded with 18 games and all 30 MLB teams scheduled to be in action, giving ample opportunities to make MLB betting picks. One of the most notable MLB matchups on Wednesday is Mariners vs. Royals at 9:40 p.m. ET in Seattle. MVP candidate Cal Raleigh will be looking to extend his lead in the MLB home run race. The SportsLine Projecting Model is calling for the Mariners to win on the money line at -183 odds (risk $183 to win $100). Raleigh is listed at +250 to hit 1+ home runs on Wednesday at DraftKings Sportsbook.
Another marquee matchup is Red Sox vs. Reds in Boston at 7:10 p.m. ET. Boston and Cincinnati will finish their suspended game from Tuesday before their night game on Wednesday. In the second game of the day, SportsLine’s model is calling for a big performance from Reds shortstop Elly De La Cruz. The 2024 MLB All-Star selection is projected to go Over 1.5 total bases on Wednesday at -128 odds. Before making any other MLB picks or building any MLB parlays, you’ll want to see the MLB predictions and betting advice from SportsLine’s proven computer model. You can also check out our MLB prop bet picks and MLB home run picks for Wednesday.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 15 of the 2025 MLB season on a profitable 39-30 run on top-rated MLB sides picks. It has excelled making home run prop picks this season, returning more than 24 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns.
The model has broken down the MLB odds for Wednesday and just revealed its top picks and MLB player props. Combining the model’s four picks into an MLB parlay would result in a payout of +1418 (risk $100 to win $1,418). New users can even take advantage of the DraftKings promo code offering $150 in bonus bets instantly with a $5 wager.
Here are its best bets for the MLB slate on Wednesday.
- Elly De La Cruz Over 1.5 total bases (-128)
- Willy Adames Over 0.5 total RBI (+196)
- Seattle Mariners money line (-183) vs. Kansas City Royals
- Washington Nationals (+1.5) on the run line vs. Detroit Tigers (-116)
- Combine these picks for a shot at a +1418 payout (odds subject to change)
Elly De La Cruz Over 1.5 total bases (-128)
De La Cruz is a rising star and one of the most dynamic players in MLB today. The 23-year-old enters Wednesday batting .279 with 18 home runs, 57 RBI, and 22 stolen bases. SportsLine gives this pick an edge of 0.6 based on the projection of 2.1 total bases and the consensus line of 1.5. New users can enhance their bet with the latest FanDuel promo code.
Willy Adames Over 0.5 total RBI (+196)
Adames and the Giants will be in Arizona to take on the Diamondbacks in a National League West rivalry game on Wednesday. The 29-year-old shortstop enters the day batting .211 with 10 home runs and 37 RBI. SportsLine gives this pick an edge of 0.2 based on the projection of 0.7 RBI for Adames on Wednesday and the consensus line of 0.5. New users can snag up to $1,500 in bonus bets with the latest BetMGM bonus code:
Seattle Mariners money line (-183) vs. Kansas City Royals
Seattle has homefield advantage in this game, that projects to be a low-scoring pitching duel. Noah Cameron (2-4, 2.79 ERA, 1.01 WHIP) will be on the mound for Kansas City, while Logan Gilbert (2-2, 3.55 ERA, 0.92 WHIP) is scheduled to start for Seattle. The SportsLine Projection Model is predicting a final score of 4.2-3.1 in the Mariners’ favor, with Seattle winning in 68% of computer simulations. New users can double their winnings on 10 bets with the latest Fanatics Sportsbook promo code:
Washington Nationals (+1.5) on the run line vs. Detroit Tigers (-116)
These teams are trending in opposite directions, with the Tigers looking like legitimate contenders in the American League, and the Nationals sitting at 14 games under the .500 mark. That said, Washington actually holds a slight advantage at starting pitcher in Game 2 of this Wednesday double-header, where MacKenzie Gore (3-8, 3.09 ERA) has quietly been solid in 2025. The SportsLine Projection Model is predicting a final score of 4.7-3.6 in the Tigers’ favor, with Washington covering in 58% of computer simulations.
Want more MLB picks for today?
You’ve seen some of the model’s MLB best bets for Wednesday. Now, get run line, total and money-line picks for every game here, all from the model that’s simulated every game 10,000 times.
Also at SportsLine:
You can also see today’s top MLB picks from expert Matt Severance, who’s on a sizzling 171-101 roll on his last 272 MLB picks. Visit SportsLine to see his best plays for today, all from the expert who’s up more than 13 units.
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